Prazosin during threat discrimination boosts memory of the safe stimulus
Access DataAbstract
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that prazosin during threat acquisition may have influenced encoding or consolidation of safety processing in particular, subsequently leading to enhanced discrimination between the safe and threatening stimuli.
ID 179
Authors
Philipp Homan, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. Qi Lin, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. James W Murrough, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA Laili Soleimani, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA Dominik R Bach, Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, 8032 Zurich, Switzerland Roger L Clem, Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA Daniela Schiller, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Year
2017
DOI of Publication
Persistent Identifier to Dataset
Where was the data collected?
Icahn School of Medicine at Mount Sinai, USA
How to Cite
Homan, P., Lin, Q., Murrough, J. W., Soleimani, L., Bach, D. R., Clem, R. L., & Schiller, D. (2017). Prazosin during threat discrimination boosts memory of the safe stimulus. Learning & Memory (Cold Spring Harbor, N.Y.), 24(11), 597–601. https://doi.org/10.1101/lm.045898.117
Participant Information
Participant Age
Participant Gender
Experimental Group
Placebo Group: - Administration of placebo 2h before acquisition Prazosin Group: - Administration of 3 mg Prazosin before acquisition (1 mg 2 h before acq., 2 mg 1.5 h before acq.)