Prazosin during threat discrimination boosts memory of the safe stimulus

Access Data

First Author

Homan

Abstract

ID 179

Authors

Year

2017

DOI of Publication

10.1101/lm.045898.117

Persistent Identifier to Dataset

10.17605/OSF.IO/74XTZ

Where was the data collected?

Icahn School of Medicine at Mount Sinai, USA

How to Cite

Homan, P., Lin, Q., Murrough, J. W., Soleimani, L., Bach, D. R., Clem, R. L., & Schiller, D. (2017). Prazosin during threat discrimination boosts memory of the safe stimulus. Learning & memory (Cold Spring Harbor, N.Y.), 24(11), 597–601. https://doi.org/10.1101/lm.045898.117

Participant Information

Participant Age

Participant Gender

Experimental Group

Placebo Group: - Administration of placebo 2h before acquisition Prazosin Group: - Administration of 3 mg Prazosin before acquisition (1 mg 2 h before acq., 2 mg 1.5 h before acq.)

Stimuli

Yes

Drug Administration

Conditioning Protocol

Differential

Instructions CS-US Contingencies

Uninstructed (whole exp)

Number of Different US

1

US Modality

electrotactile

Number of Different CS+

1

CS+ 1: Reinforcement Rate (%)

43

CS+ 2: Reinforcement Rate (%)

CS+ 3: Reinforcement Rate (%)

Number of Different CS-

1

CS Modality

visual
No

Data Collected During MRI

Physiological Measures

trialwise & untransformed measured Yes Yes
Skin Conductance Response
No No
Skin Conductance Level
No No
Pupil Size
No No
Fear Potentiated Startle/Startle EMG
No No
Heart Rate

Ratings

No

US Expectancy

No

US Intensity Rating

No

CS Valence

No

CS Arousal

No

CS Fear

No

CS Stress

No

CS Anxiety

No

Contingency Awareness

Questionnaires

STAI-T